靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

REACPATH

R-HSA-5626978:TNFR1-mediated ceramide production

REACPATH

R-HSA-5668541:TNFR2 non-canonical NF-kB pathway

REACPATH

R-HSA-75893:TNF signaling

NET_PATH

NetPath_11:TCR Signaling Pathway

NET_PATH

NetPath_13:IL1 Signaling Pathway

NET_PATH

NetPath_14:IL2 Signaling Pathway

NET_PATH

NetPath_15:IL3 Signaling Pathway

NET_PATH

NetPath_16:IL4 Signaling Pathway

NET_PATH

NetPath_21:RANKL Signaling Pathway

NET_PATH

NetPath_22:Leptin Signaling Pathway

INTEPATH

amb2_neutrophils_pathway:amb2 Integrin signaling

INTEPATH

angiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling

INTEPATH

anthraxpathway:Cellular roles of Anthrax toxin

INTEPATH

caspase_pathway:Caspase Cascade in Apoptosis

INTEPATH

cd8tcrdownstreampathway:Downstream signaling in naïve CD8+ T cells

INTEPATH

ceramide_pathway:Ceramide signaling pathway

INTEPATH

hdac_classi_pathway:Signaling events mediated by HDAC Class I

INTEPATH

hivnefpathway:HIV-1 Nef: Negative effector of Fas and TNF-alpha

INTEPATH

il23pathway:IL23-mediated signaling events

INTEPATH

il27pathway:IL27-mediated signaling events

目标的 KEGG 通路数据

标题	内容
hsa04060	Cytokine-cytokine receptor interaction
hsa04064	NF-kappa B signaling pathway
hsa04071	Sphingolipid signaling pathway
hsa04150	mTOR signaling pathway
hsa04210	Apoptosis
hsa04350	TGF-beta signaling pathway
hsa04380	Osteoclast differentiation
hsa04612	Antigen processing and presentation
hsa04620	Toll-like receptor signaling pathway
hsa04621	NOD-like receptor signaling pathway
hsa04622	RIG-I-like receptor signaling pathway
hsa04640	Hematopoietic cell lineage
hsa04650	Natural killer cell mediated cytotoxicity
hsa04660	T cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04668	TNF signaling pathway
hsa04920	Adipocytokine signaling pathway
hsa04930	Type II diabetes mellitus
hsa04932	Non-alcoholic fatty liver disease (NAFLD)
hsa04940	Type I diabetes mellitus
hsa05010	Alzheimer's disease
hsa05014	Amyotrophic lateral sclerosis (ALS)
hsa05133	Pertussis
hsa05134	Legionellosis
hsa05140	Leishmaniasis
hsa05142	Chagas disease (American trypanosomiasis)
hsa05143	African trypanosomiasis
hsa05144	Malaria
hsa05145	Toxoplasmosis
hsa05146	Amoebiasis
hsa05152	Tuberculosis
hsa05160	Hepatitis C
hsa05161	Hepatitis B
hsa05164	Influenza A
hsa05166	HTLV-I infection
hsa05168	Herpes simplex infection
hsa05205	Proteoglycans in cancer
hsa05310	Asthma
hsa05321	Inflammatory bowel disease (IBD)
hsa05322	Systemic lupus erythematosus
hsa05323	Rheumatoid arthritis
hsa05330	Allograft rejection
hsa05332	Graft-versus-host disease
hsa05410	Hypertrophic cardiomyopathy (HCM)
hsa05414	Dilated cardiomyopathy
hsa04010	MAPK signaling pathway

目标的 Wiki 路径数据

标题	内容
WP75	Toll-like receptor signaling pathway
WP727	Monoamine Transport
WP706	SIDS Susceptibility Pathways
WP560	TGF Beta Signaling Pathway
WP530	Cytokines and Inflammatory Response
WP382	MAPK Signaling Pathway
WP3297	EV release from cardiac cells and their functional effects
WP314	FAS pathway and Stress induction of HSP regulation
WP2864	Apoptosis-related network due to altered Notch3 in ovarian cancer
WP2795	Cardiac Hypertrophic Response
WP2751	Transcriptional Regulation of White Adipocyte Differentiation
WP2586	Aryl Hydrocarbon Receptor
WP254	Apoptosis
WP2513	Nanoparticle triggered regulated necrosis
WP2447	Amyotrophic lateral sclerosis (ALS)
WP236	Adipogenesis
WP2328	Allograft Rejection
WP231	TNF alpha Signaling Pathway
WP2036	TWEAK Signaling Pathway
WP1814	Extrinsic Pathway for Apoptosis
WP176	Folate Metabolism
WP1544	MicroRNAs in cardiomyocyte hypertrophy
WP1533	Vitamin B12 Metabolism
WP15	Selenium Micronutrient Network
WP1449	Regulation of toll-like receptor signaling pathway
WP129	Matrix Metalloproteinases

目标的蛋白质ID

标题	内容
TARGETID	T20178
UNIPROID	TNFA_HUMAN
TARGNAME	Tumor necrosis factor (TNF)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Tumor necrosis factor (TNF)	MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

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