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靶点信息20(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Oncostatin-M (OSM)
TARGTYPE
Clinical trial target
FUNCTION
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
SEQUENCE
MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR
KEGGPATH
hsa04060:Cytokine-cytokine receptor interaction
KEGGPATH
hsa04151:PI3K-Akt signaling pathway
KEGGPATH
hsa04630:Jak-STAT signaling pathway
WIKIPATH
WP236:Adipogenesis
WIKIPATH
WP2374:Oncostatin M Signaling Pathway
NET_PATH
NetPath_14:IL2 Signaling Pathway
INTEPATH
gmcsf_pathway:GMCSF-mediated signaling events
INTEPATH
il3_pathway:IL3-mediated signaling events
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04060 |
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| hsa04151 |
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| hsa04630 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
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| UNIPROID |
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| TARGNAME |
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| TARGTYPE |
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