TARGETID

T18639

FORMERID

TTDR00925

UNIPROID

FGF1_HUMAN

TARGNAME

Heparin-binding growth factor 1 (FGF1)

GENENAME

FGF1

TARGTYPE

Clinical trial target

SYNONYMS

HBGF-1; Fibroblast growth factor 1; FGFA; FGF-1; Endothelial cell growth factor; ECGF-beta; ECGF; Beta-endothelial cell growth factor; Acidic fibroblast growth factor; AFGF

FUNCTION

Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis. Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration.

PDBSTRUC

4YOL; 4XKI; 4QO3; 4QC4; 4QBV

BIOCLASS

Growth factor

SEQUENCE

MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD

DRUGINFO

CVBT-141H

DRUGINFO

Riferminogene pecaplasmid

DRUGINFO

5-AMINO-NAPHTALENE-2-MONOSULFONATE

DRUGINFO

Formic Acid

DRUGINFO

N,O6-Disulfo-Glucosamine

DRUGINFO

Naphthalene Trisulfonate

DRUGINFO

O2-Sulfo-Glucuronic Acid

DRUGINFO

Sucrose Octasulfate

KEGGPATH

hsa04010:MAPK signaling pathway