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靶点信息57(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Interleukin-1 alpha (IL1A)
TARGTYPE
Clinical trial target
SYNONYMS
IL1F1; IL-1 alpha; Hematopoietin-1
FUNCTION
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
PDBSTRUC
5UC6; 2L5X; 2KKI; 2ILA; 1ITA
BIOCLASS
Cytokine: interleukin
SEQUENCE
MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNQKSFYHVSYGPLHEGCMDQSVSLSISETSKTSKLTFKESMVVVATNGKVLKKRRLSLSQSITDDDLEAIANDSEEEIIKPRSAPFSFLSNVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQILENQA
DRUGINFO
Interleukin-1-alpha - Amgen/Roche
KEGGPATH
hsa04010:MAPK signaling pathway
KEGGPATH
hsa04060:Cytokine-cytokine receptor interaction
KEGGPATH
hsa04210:Apoptosis
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04010 |
|
| hsa04060 |
|
| hsa04210 |
|
| hsa04380 |
|
| hsa04640 |
|
| hsa04932 |
|
| hsa04940 |
|
| hsa05020 |
|
| hsa05132 |
|
| hsa05133 |
|
| hsa05140 |
|
| hsa05152 |
|
| hsa05162 |
|
| hsa05164 |
|
| hsa05321 |
|
| hsa05323 |
|
| hsa05332 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP706 |
|
| WP69 |
|
| WP615 |
|
| WP530 |
|
| WP516 |
|
| WP382 |
|
| WP314 |
|
| WP2849 |
|
| WP2637 |
|
| WP2431 |
|
| WP2328 |
|
| WP195 |
|
| WP1839 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Interleukin-1 alpha (IL1A) |
|