靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

REACPATH

R-HSA-5654720:PI-3K cascade:FGFR4

REACPATH

R-HSA-5654726:Negative regulation of FGFR1 signaling

REACPATH

R-HSA-5654727:Negative regulation of FGFR2 signaling

REACPATH

R-HSA-5654732:Negative regulation of FGFR3 signaling

REACPATH

R-HSA-5654733:Negative regulation of FGFR4 signaling

REACPATH

R-HSA-877312:Regulation of IFNG signaling

REACPATH

R-HSA-909733:Interferon alpha/beta signaling

REACPATH

R-HSA-912694:Regulation of IFNA signaling

REACPATH

R-HSA-936964:Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

NET_PATH

NetPath_7:TGF_beta_Receptor Signaling Pathway

INTEPATH

angiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling

INTEPATH

avb3_integrin_pathway:Integrins in angiogenesis

INTEPATH

cxcr4_pathway:CXCR4-mediated signaling events

INTEPATH

epopathway:EPO signaling pathway

INTEPATH

erbb1_receptor_proximal_pathway:EGF receptor (ErbB1) signaling pathway

INTEPATH

erbb2erbb3pathway:ErbB2/ErbB3 signaling events

INTEPATH

fcer1pathway:Fc-epsilon receptor I signaling in mast cells

INTEPATH

fgf_pathway:FGF signaling pathway

INTEPATH

gmcsf_pathway:GMCSF-mediated signaling events

INTEPATH

ifngpathway:IFN-gamma pathway

目标的 KEGG 通路数据

标题	内容
hsa04014	Ras signaling pathway
hsa04630	Jak-STAT signaling pathway
hsa04650	Natural killer cell mediated cytotoxicity
hsa04670	Leukocyte transendothelial migration
hsa04722	Neurotrophin signaling pathway
hsa04920	Adipocytokine signaling pathway
hsa05120	Epithelial cell signaling in Helicobacter pylori infection
hsa05168	Herpes simplex infection
hsa05205	Proteoglycans in cancer
hsa05211	Renal cell carcinoma
hsa05220	Chronic myeloid leukemia

目标的 Wiki 路径数据

标题	内容
WP69	TCR Signaling Pathway
WP619	Type II interferon signaling (IFNG)
WP585	Interferon type I signaling pathways
WP49	IL-2 Signaling Pathway
WP481	Insulin Signaling
WP437	EGF/EGFR Signaling Pathway
WP395	IL-4 Signaling Pathway
WP364	IL-6 signaling pathway
WP313	Signaling of Hepatocyte Growth Factor Receptor
WP304	Kit receptor signaling pathway
WP286	IL-3 Signaling Pathway
WP2752	MyD88-independent cascade
WP2713	Signaling by SCF-KIT
WP2704	Interleukin-6 signaling
WP2678	Prolactin receptor signaling
WP2677	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
WP2653	PIP3 activates AKT signaling
WP2593	JAK/STAT
WP2526	PDGF Pathway
WP244	Alpha 6 Beta 4 signaling pathway
WP2380	BDNF signaling pathway
WP2374	Oncostatin M Signaling Pathway
WP2332	Interleukin-11 Signaling Pathway
WP23	B Cell Receptor Signaling Pathway
WP2263	Prostate Cancer
WP2253	Pilocytic astrocytoma
WP2203	TSLP Signaling Pathway
WP2034	Leptin signaling pathway
WP195	IL-1 signaling pathway
WP1916	Signaling by PDGF
WP1911	Signaling by FGFR
WP1910	Signaling by EGFR
WP1909	Signal regulatory protein (SIRP) family interactions
WP1885	Platelet homeostasis
WP1868	Netrin-1 signaling
WP1840	Interleukin-3, 5 and GM-CSF signaling
WP1835	Interferon alpha/beta signaling
WP1799	Costimulation by the CD28 family
WP1794	Cell surface interactions at the vascular wall
WP1591	Heart Development
WP127	IL-5 Signaling Pathway

目标的蛋白质ID

标题	内容
TARGETID	T13057
UNIPROID	PTN11_HUMAN
TARGNAME	Protein-tyrosine phosphatase SHP-2 (PTPN11)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Protein-tyrosine phosphatase SHP-2 (PTPN11)	MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR

标题

内容

Protein-tyrosine phosphatase SHP-2 (PTPN11)

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