TARGETID

T06841

FORMERID

TTDI01808

UNIPROID

IL23A_HUMAN

TARGNAME

Interleukin-23 (IL23)

GENENAME

IL23A

TARGTYPE

Successful target

SYNONYMS

UNQ2498/PRO5798; SGRF; P40 subunit of interleukin-23; Interleukin-23 subunit p19; Interleukin-23 subunit alpha; Interleukin 23 subunit alpha; IL-23p19; IL-23-A; IL-23 subunit alpha; IL-23

FUNCTION

IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity.

PDBSTRUC

5NJD; 5MZV; 5MXA; 5MJ4; 5MJ3

BIOCLASS

Cytokine: interleukin

SEQUENCE

MLGSRAVMLLLLLPWTAQGRAVPGGSSPAWTQCQQLSQKLCTLAWSAHPLVGHMDLREEGDEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIHQGLIFYEKLLGSDIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVFAHGAATLSP

DRUGINFO

CNTO-1959

DRUGINFO

Risankizumab

DRUGINFO

Tildrakizumab

DRUGINFO

Ustekinumab

DRUGINFO

BI 655066

DRUGINFO

MK-3222

DRUGINFO

CNT0-1959

DRUGINFO

AMG-139

DRUGINFO

mRNA-2752