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靶点信息42(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Interleukin-18 (IL18)
TARGTYPE
Clinical trial target
SYNONYMS
Interleukin-1 gamma; Interferon-gamma inducing factor; Interferon gamma-inducing factor; Iboctadekin; IL1F4; IL-18; IL-1 gamma; IGIF; IFN-gamma-inducing factor
FUNCTION
Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses.
PDBSTRUC
4XFU; 4XFT; 4XFS; 4R6U; 4HJJ
BIOCLASS
Cytokine: interleukin
SEQUENCE
MAAEPVEDNCINFVAMKFIDNTLYFIAEDDENLESDYFGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDELGDRSIMFTVQNED
DRUGINFO
Iboctadekin + Doxil
DRUGINFO
Iboctadekin + rituximab
KEGGPATH
hsa04060:Cytokine-cytokine receptor interaction
KEGGPATH
hsa04621:NOD-like receptor signaling pathway
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04060 |
|
| hsa04621 |
|
| hsa04623 |
|
| hsa05132 |
|
| hsa05134 |
|
| hsa05143 |
|
| hsa05144 |
|
| hsa05152 |
|
| hsa05164 |
|
| hsa05321 |
|
| hsa05323 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP516 |
|
| WP2865 |
|
| WP2355 |
|
| WP1433 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Interleukin-18 (IL18) |
|