TARGETID

T06421

FORMERID

TTDS00492

UNIPROID

INAR2_HUMAN

TARGNAME

Interferon alpha/beta receptor 2 (IFNAR2)

GENENAME

IFNAR2

TARGTYPE

Successful target

SYNONYMS

Type I interferon receptor 2; Type I interferon receptor; Interferon alpha/beta receptor; Interferon alpha binding protein; IFNARB; IFNABR; IFN-alpha/beta receptor 2; IFN-alpha-REC; IFN-alpha binding protein; IFN-R-2; IFN-R

FUNCTION

Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Associates with IFNAR1 to form the type I interferon receptor.

PDBSTRUC

3SE4; 3SE3; 3S9D; 3S8W; 2LAG

BIOCLASS

Cytokine receptor

SEQUENCE

MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAESAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMDMVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLIDPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGRITFNVDLNSVFLRVLDDEDSDDLEAPLMLSSHLEEMVDPEDPDNVQSNHLLASGEGTQPTFPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR

DRUGINFO

Interferon Alfa-2b, Recombinant

DRUGINFO

Interferon alfacon-1

DRUGINFO

Interferon alfa-n1

DRUGINFO

Interferon beta-1b

DRUGINFO

Sifalimumab

DRUGINFO

Anifrolumab

DRUGINFO

Alfa-interferon

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04151:PI3K-Akt signaling pathway