靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

REACPATH

R-HSA-1257604:PIP3 activates AKT signaling

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R-HSA-198203:PI3K/AKT activation

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R-HSA-2029485:Role of phospholipids in phagocytosis

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R-HSA-210993:Tie2 Signaling

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R-HSA-2219530:Constitutive Signaling by Aberrant PI3K in Cancer

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R-HSA-2424491:DAP12 signaling

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R-HSA-2730905:Role of LAT2/NTAL/LAB on calcium mobilization

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R-HSA-373753:Nephrin interactions

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R-HSA-392451:G beta:gamma signalling through PI3Kgamma

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R-HSA-4420097:VEGFA-VEGFR2 Pathway

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R-HSA-512988:Interleukin-3, 5 and GM-CSF signaling

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R-HSA-912526:Interleukin receptor SHC signaling

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R-HSA-912631:Regulation of signaling by CBL

INTEPATH

cxcr3pathway:CXCR3-mediated signaling events

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cxcr4_pathway:CXCR4-mediated signaling events

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erbb1_downstream_pathway:ErbB1 downstream signaling

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erbb1_internalization_pathway:Internalization of ErbB1

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erbb1_receptor_proximal_pathway:EGF receptor (ErbB1) signaling pathway

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erbb2erbb3pathway:ErbB2/ErbB3 signaling events

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erbb4_pathway:ErbB4 signaling events

目标的 KEGG 通路数据

标题	内容
hsa04960	Aldosterone-regulated sodium reabsorption
hsa04973	Carbohydrate digestion and absorption
hsa05100	Bacterial invasion of epithelial cells
hsa05142	Chagas disease (American trypanosomiasis)
hsa05145	Toxoplasmosis
hsa05146	Amoebiasis
hsa05160	Hepatitis C
hsa05161	Hepatitis B
hsa05162	Measles
hsa05164	Influenza A
hsa05166	HTLV-I infection
hsa05169	Epstein-Barr virus infection
hsa05200	Pathways in cancer
hsa05203	Viral carcinogenesis
hsa05205	Proteoglycans in cancer
hsa05210	Colorectal cancer
hsa05211	Renal cell carcinoma
hsa05212	Pancreatic cancer
hsa05213	Endometrial cancer
hsa05214	Glioma
hsa05215	Prostate cancer
hsa05218	Melanoma
hsa05220	Chronic myeloid leukemia
hsa05221	Acute myeloid leukemia
hsa05222	Small cell lung cancer
hsa05223	Non-small cell lung cancer
hsa05230	Central carbon metabolism in cancer
hsa05231	Choline metabolism in cancer
hsa04071	Sphingolipid signaling pathway
hsa04150	mTOR signaling pathway
hsa04151	PI3K-Akt signaling pathway
hsa04152	AMPK signaling pathway
hsa04210	Apoptosis
hsa04261	Adrenergic signaling in cardiomyocytes
hsa04370	VEGF signaling pathway
hsa04380	Osteoclast differentiation
hsa04510	Focal adhesion
hsa04550	Signaling pathways regulating pluripotency of stem cells
hsa04611	Platelet activation
hsa04620	Toll-like receptor signaling pathway
hsa04630	Jak-STAT signaling pathway
hsa04650	Natural killer cell mediated cytotoxicity
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04666	Fc gamma R-mediated phagocytosis
hsa04668	TNF signaling pathway
hsa04670	Leukocyte transendothelial migration
hsa04722	Neurotrophin signaling pathway
hsa04725	Cholinergic synapse
hsa04750	Inflammatory mediator regulation of TRP channels
hsa04810	Regulation of actin cytoskeleton
hsa04910	Insulin signaling pathway
hsa04914	Progesterone-mediated oocyte maturation
hsa04915	Estrogen signaling pathway
hsa04917	Prolactin signaling pathway
hsa04919	Thyroid hormone signaling pathway
hsa04921	Oxytocin signaling pathway
hsa04923	Regulation of lipolysis in adipocytes
hsa04930	Type II diabetes mellitus
hsa04932	Non-alcoholic fatty liver disease (NAFLD)
hsa00562	Inositol phosphate metabolism
hsa04012	ErbB signaling pathway
hsa04014	Ras signaling pathway
hsa04015	Rap1 signaling pathway
hsa04022	cGMP-PKG signaling pathway
hsa04024	cAMP signaling pathway
hsa04062	Chemokine signaling pathway
hsa04066	HIF-1 signaling pathway
hsa04068	FoxO signaling pathway
hsa04070	Phosphatidylinositol signaling system

目标的 Wiki 路径数据

标题	内容
WP1794	Cell surface interactions at the vascular wall
WP1544	MicroRNAs in cardiomyocyte hypertrophy
WP1449	Regulation of toll-like receptor signaling pathway
WP1403	AMPK Signaling
WP75	Toll-like receptor signaling pathway
WP710	DNA Damage Response (only ATM dependent)
WP524	G13 Signaling Pathway
WP51	Regulation of Actin Cytoskeleton
WP481	Insulin Signaling
WP2759	Fc epsilon receptor (FCERI) signaling
WP2747	PI Metabolism
WP2732	Interleukin-2 signaling
WP2719	Fcgamma receptor (FCGR) dependent phagocytosis
WP2694	DAP12 interactions
WP2677	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
WP2653	PIP3 activates AKT signaling
WP2261	Signaling Pathways in Glioblastoma
WP1927	TCR signaling
WP1916	Signaling by PDGF
WP1913	Signaling by Insulin receptor
WP1873	NGF signalling via TRKA from the plasma membrane
WP1867	Nephrin interactions
WP1840	Interleukin-3, 5 and GM-CSF signaling
WP1826	GPVI-mediated activation cascade

目标的蛋白质ID

标题	内容
TARGETID	T05031
UNIPROID	PK3CB_HUMAN
TARGNAME	PI3-kinase beta (PIK3CB)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
PI3-kinase beta (PIK3CB)	MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGEKLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS

标题

内容

PI3-kinase beta (PIK3CB)

MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGEKLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS

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