靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T03818

FORMERID

TTDR01386

UNIPROID

PPARG_HUMAN

TARGNAME

PPAR-gamma messenger RNA (PPARG mRNA)

GENENAME

PPARG

TARGTYPE

Literature-reported target

SYNONYMS

Transcription factor PPAR gamma receptor (mRNA); Peroxisome proliferator-activated receptor gamma (mRNA); PPARgamma (mRNA); PPAR-gamma (mRNA); Nuclear receptor subfamily 1 group C member 3 (mRNA); NR1C3 (mRNA)

FUNCTION

Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels. Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids.

PDBSTRUC

6MD4; 6MD2; 6MD1; 6MD0; 6MCZ

BIOCLASS

mRNA target

SEQUENCE

MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY

DRUGINFO

Bardoxolone methyl

DRUGINFO

AD-5075

DRUGINFO

(9Z,12E)-12-nitrooctadeca-9,12-dienoic acid

Investigative

DRUGINFO

D0W9WU

(E)-10-Nitrohexadec-9-enoic Acid

Investigative

DRUGINFO

D06IHG

(E)-10-nitrooctadec-9-enoic acid

Investigative

DRUGINFO

D0M9LL

(E)-12-Nitrooctadec-12-enoic Acid

Investigative

DRUGINFO

D0P5QM

(E)-13-Nitrooctadec-12-enoic Acid

Investigative

DRUGINFO

D0Q4UD

(E)-5-Nitrooctadec-5-enoic Acid

Investigative

DRUGINFO

D0Z4NW

(E)-6-Nitrooctadec-5-enoic Acid

Investigative

目标的 KEGG 通路数据

标题	内容
hsa03320	PPAR signaling pathway
hsa04152	AMPK signaling pathway
hsa04380	Osteoclast differentiation
hsa05016	Huntington's disease
hsa05200	Pathways in cancer
hsa05202	Transcriptional misregulation in cancer
hsa05216	Thyroid cancer

目标的 Wiki 路径数据

标题	内容
WP363	Wnt Signaling Pathway Netpath
WP299	Nuclear Receptors in Lipid Metabolism and Toxicity
WP2895	Differentiation of white and brown adipocyte
WP2797	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
WP2751	Transcriptional Regulation of White Adipocyte Differentiation
WP236	Adipogenesis
WP1982	SREBP signalling
WP170	Nuclear Receptors

目标的蛋白质ID

标题	内容
TARGETID	T03818
UNIPROID	PPARG_HUMAN
TARGNAME	PPAR-gamma messenger RNA (PPARG mRNA)
TARGTYPE	Research target

目标的序列数据

标题	内容
PPAR-gamma messenger RNA (PPARG mRNA)	MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY

标题

内容

PPAR-gamma messenger RNA (PPARG mRNA)

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