TARGETID

T03573

FORMERID

TTDNC00464

UNIPROID

FCG2B_HUMAN

TARGNAME

Immunoglobulin gamma Fc receptor IIB (FCGR2B)

GENENAME

FCGR2B

TARGTYPE

Clinical trial target

SYNONYMS

Low affinity immunoglobulin gamma Fc region receptor II-b; IgG Fc receptor II-b; FcRII-b; Fc-gamma-RIIb; Fc-gamma RII-b; FCG2B; CDw32 B; CD32 B

FUNCTION

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

PDBSTRUC

5OCC; 3WJJ; 2FCB

BIOCLASS

Immunoglobulin

SEQUENCE

MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISALPGYPECREMGETLPEKPANPTNPDEADKVGAENTITYSLLMHPDALEEPDDQNRI

DRUGINFO

Xmab 5871

DRUGINFO

BI 1206

DRUGINFO

MGD010

KEGGPATH

hsa04145:Phagosome

KEGGPATH

hsa04380:Osteoclast differentiation

KEGGPATH

hsa04662:B cell receptor signaling pathway

KEGGPATH

hsa04666:Fc gamma R-mediated phagocytosis

KEGGPATH

hsa05150:Staphylococcus aureus infection

KEGGPATH

hsa05152:Tuberculosis