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靶点信息11(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Mutated KRAS (mKRAS)
TARGTYPE
Clinical trial target
SYNONYMS
c-Ki-ras (mutated); c-K-ras (mutated); RASK2 (mutated); Ki-Ras (mutated); KRAS2 (mutated); K-Ras 2 (mutated); GTPase KRas (mutated)
FUNCTION
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.
PDBSTRUC
6N2K; 6N2J; 6H47; 6H46; 6GQY
SEQUENCE
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
DRUGINFO
GI-4000 + gemcitabine
目标的蛋白质ID
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目标的序列数据
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| Mutated KRAS (mKRAS) |
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