靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T02808

FORMERID

TTDI01922

UNIPROID

IFNB_HUMAN

TARGNAME

Interferon-beta (IFNB1)

GENENAME

IFNB1

TARGTYPE

Successful target

SYNONYMS

Interferon beta; IFNbeta; IFNB; IFN-beta; IFB; Fibroblast interferon

FUNCTION

Has antiviral, antibacterial and anticancer activities.

PDBSTRUC

1AU1

BIOCLASS

Cytokine: interferon

SEQUENCE

MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFDIPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLKTVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINRLTGYLRN

DRUGINFO

D0V4JQ

Interferon beta-1a

Approved

DRUGINFO

D04YXL

PEGylated IFN beta 1-a

DRUGINFO

PLEGRIDY

DRUGINFO

Biferonex

DRUGINFO

FP-1201

DRUGINFO

NU-100

DRUGINFO

AZ-01, PEGylated interferon-beta

DRUGINFO

Interferon beta 1a

DRUGINFO

PF-06823859

目标的 KEGG 通路数据

标题	内容
hsa04060	Cytokine-cytokine receptor interaction
hsa04151	PI3K-Akt signaling pathway
hsa04380	Osteoclast differentiation
hsa04620	Toll-like receptor signaling pathway
hsa04622	RIG-I-like receptor signaling pathway
hsa04623	Cytosolic DNA-sensing pathway
hsa04630	Jak-STAT signaling pathway
hsa04650	Natural killer cell mediated cytotoxicity
hsa05142	Chagas disease (American trypanosomiasis)
hsa05152	Tuberculosis
hsa05160	Hepatitis C
hsa05161	Hepatitis B
hsa05162	Measles
hsa05164	Influenza A
hsa05168	Herpes simplex infection

目标的 Wiki 路径数据

标题	内容
WP75	Toll-like receptor signaling pathway
WP619	Type II interferon signaling (IFNG)
WP615	Senescence and Autophagy in Cancer
WP530	Cytokines and Inflammatory Response
WP262	EBV LMP1 signaling
WP1904	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
WP1835	Interferon alpha/beta signaling
WP1449	Regulation of toll-like receptor signaling pathway
WP12	Osteoclast Signaling

目标的蛋白质ID

标题	内容
TARGETID	T02808
UNIPROID	IFNB_HUMAN
TARGNAME	Interferon-beta (IFNB1)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Interferon-beta (IFNB1)	MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFDIPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLKTVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINRLTGYLRN

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