TARGETID

T00239

FORMERID

TTDR00086

UNIPROID

IL4_HUMAN

TARGNAME

Interleukin-4 (IL4)

GENENAME

IL4

TARGTYPE

Clinical trial target

SYNONYMS

Pitrakinra; Lymphocyte stimulatory factor 1; IL-4; Binetrakin; BSF-1; B-cell stimulatory factor 1

FUNCTION

It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. Participates in at least several B-cell activation processes as well as of other cell types.

PDBSTRUC

5FHX; 4YDY; 3QB7; 3BPN; 3BPL

BIOCLASS

Cytokine: interleukin

SEQUENCE

MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS

DRUGINFO

IL-4R

DRUGINFO

Pascolizumab

DRUGINFO

PEGylated pitrakinra

DRUGINFO

Romilkimab

DRUGINFO

SAR-156597

DRUGINFO

Tepoxalin

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04151:PI3K-Akt signaling pathway

KEGGPATH

hsa04630:Jak-STAT signaling pathway